The review included 29 randomized controlled trials involving more than 2,700 preterm and full‑term neonates. It showed that infants who received sucrose just before or during the needle insertion probably experienced less pain than those who received no intervention, water, or only standard comfort care. Sucrose was found to lower pain scores during the procedure and for up to one minute afterward.
Dr Mariana Bueno from the University of Toronto, the lead author of the review, said: “Newborn babies undergo frequent needle procedures in hospital without any pain relief or comforting measures, even though older children and adults rarely have these procedures done without pain care.
The evidence shows that a small amount of sucrose given just before the procedure is a simple, fast, and effective way to reduce that pain. Our review helps clinicians use this evidence more confidently and consistently in practice.”
The review also found that sucrose appeared to be more effective than the use of pacifiers alone for reducing pain. However, evidence comparing sucrose with other comforting measures such as skin‑to‑skin care was limited.
Importantly, no studies reported harmful side effects such as gagging or pauses in breathing when sucrose was used in the small amounts required for pain relief.
Researchers emphasized that sucrose can be given orally in very small doses and that this simple intervention could help inform clearer clinical guidelines for neonatal pain management worldwide.
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