![\"\"](\"https:\/\/fr.igihe.com\/IMG\/jpg\/une_substance.jpg\")
<\/figure>\nLa substance est le fruit de plusieurs ann\u00e9es de recherche principalement r\u00e9alis\u00e9e par The Scripps Research Institute -centre de recherche \u00e0 but non lucratif bas\u00e9 en Floride- et financ\u00e9e par l’Institut public de recherche am\u00e9ricain sur les maladies infectieuses NIAID.<\/p>\n
Ce \u00abcompos\u00e9\u00bb baptis\u00e9 eCD4-Ig offre une \u00abtr\u00e8s, tr\u00e8s forte protection\u00bb contre le VIH, explique le Pr Farzan qui s’appuie sur une exp\u00e9rience men\u00e9e sur des singes d\u00e9crite dans une lettre publi\u00e9e mercredi dans la revue scientifique britannique Nature.<\/p>\n
{{Une protection pendant au moins 34 semaines}}<\/p>\n
L’exp\u00e9rimentation conduite sur des macaques rh\u00e9sus a montr\u00e9 que cette substance, inject\u00e9e en une seule fois, \u00e9tait capable de prot\u00e9ger les singes de l’\u00e9quivalent du sida chez eux sur une dur\u00e9e d’au moins huit mois. Pour assurer cet effet prolong\u00e9, eCD4-Ig a \u00e9t\u00e9 associ\u00e9 \u00e0 un virus de type ad\u00e9no-associ\u00e9 (AAV), inoffensif mais capable de s’introduire dans les cellules et de leur faire fabriquer ind\u00e9finiment la prot\u00e9ine protectrice afin de cr\u00e9er un effet anti-sida de longue dur\u00e9e.<\/p>\n
Apr\u00e8s avoir \u00e9t\u00e9 trait\u00e9s avec ce cocktail, les macaques ont \u00e9t\u00e9 soumis \u00e0 des doses de plus en plus fortes de la version singe du virus du sida (SHIV-AD8). Aucun de ces animaux n’a d\u00e9velopp\u00e9 d’infection contrairement aux singes non trait\u00e9s avec eCD4-Ig et utilis\u00e9s comme t\u00e9moin. <\/p>\n
Les donn\u00e9es publi\u00e9es mercredi dans Nature montrent une protection efficace pendant au moins 34 semaines malgr\u00e9 des doses de SHIV quatre fois sup\u00e9rieures \u00e0 celles ayant suffi \u00e0 infecter les macaques t\u00e9moins.<\/p>\n","protected":false},"excerpt":{"rendered":"
{ {{Un petit pas pour le singe, un grand pas pour l’homme? Une substance anti-sida mise au point par une \u00e9quipe am\u00e9ricaine s’est av\u00e9r\u00e9e efficace pendant des mois sur des singes, offrant la perspective d’un traitement \u00e0 effet prolong\u00e9 contre le VIH, a annonc\u00e9 mercredi la revue scientifique Nature.}} } \u00abNous avons d\u00e9velopp\u00e9 un inhibiteur […]<\/p>\n","protected":false},"author":453,"featured_media":4000033958,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7534],"tags":[7620],"byline":[8169],"hashtag":[],"class_list":["post-13416","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciences-technologies","tag-internationalnews","byline-20-minutes-fr"],"bylines":[{"id":8169,"name":"20 minutes.fr","slug":"20-minutes-fr","description":"","image":{"id":0,"url":"https:\/\/secure.gravatar.com\/avatar\/?s=96&d=mm&f=y&r=g","alt":"Default avatar","title":"Default avatar","caption":"","mime_type":"image\/jpeg","sizes":[]},"user_id":null}],"contributors":[{"id":8169,"name":"20 minutes.fr","slug":"20-minutes-fr","description":"","image":{"id":0,"url":"https:\/\/secure.gravatar.com\/avatar\/?s=96&d=mm&f=y&r=g","alt":"Default avatar","title":"Default avatar","caption":"","mime_type":"image\/jpeg","sizes":[]},"user_id":null}],"featured_image":{"id":4000033958,"url":"https:\/\/fr-images.igihe.com\/IMG\/logo\/arton13416.jpg","alt":"","caption":"","mime_type":"image\/jpeg","width":0,"height":0,"sizes":{"thumbnail":{"url":"https:\/\/fr-images.igihe.com\/IMG\/logo\/arton13416.jpg","width":1,"height":1},"medium":{"url":"https:\/\/fr-images.igihe.com\/IMG\/logo\/arton13416.jpg","width":1,"height":1},"medium_large":{"url":"https:\/\/fr-images.igihe.com\/IMG\/logo\/arton13416.jpg","width":1,"height":1},"large":{"url":"https:\/\/fr-images.igihe.com\/IMG\/logo\/arton13416.jpg","width":1,"height":1},"full":{"url":"https:\/\/fr-images.igihe.com\/IMG\/logo\/arton13416.jpg","width":0,"height":0}}},"_links":{"self":[{"href":"https:\/\/new.igihe.com\/french\/wp-json\/wp\/v2\/posts\/13416","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/new.igihe.com\/french\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/new.igihe.com\/french\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/new.igihe.com\/french\/wp-json\/wp\/v2\/users\/453"}],"replies":[{"embeddable":true,"href":"https:\/\/new.igihe.com\/french\/wp-json\/wp\/v2\/comments?post=13416"}],"version-history":[{"count":0,"href":"https:\/\/new.igihe.com\/french\/wp-json\/wp\/v2\/posts\/13416\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/new.igihe.com\/french\/wp-json\/wp\/v2\/media\/4000033958"}],"wp:attachment":[{"href":"https:\/\/new.igihe.com\/french\/wp-json\/wp\/v2\/media?parent=13416"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/new.igihe.com\/french\/wp-json\/wp\/v2\/categories?post=13416"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/new.igihe.com\/french\/wp-json\/wp\/v2\/tags?post=13416"},{"taxonomy":"byline","embeddable":true,"href":"https:\/\/new.igihe.com\/french\/wp-json\/wp\/v2\/byline?post=13416"},{"taxonomy":"hashtag","embeddable":true,"href":"https:\/\/new.igihe.com\/french\/wp-json\/wp\/v2\/hashtag?post=13416"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}