{"id":29254,"date":"2016-10-08T23:03:41","date_gmt":"2016-10-08T23:03:41","guid":{"rendered":"https:\/\/new.igihe.com\/food-poisoning-bacteria-may-be-behind-crohn-s\/"},"modified":"2016-10-08T23:03:34","modified_gmt":"2016-10-08T23:03:34","slug":"food-poisoning-bacteria-may-be-behind-crohn-s","status":"publish","type":"post","link":"https:\/\/new.igihe.com\/english\/food-poisoning-bacteria-may-be-behind-crohn-s\/","title":{"rendered":"Food-poisoning bacteria may be behind Crohn&#8217;s disease"},"content":{"rendered":"<p>{People who retain a particular bacterium in their gut after a bout of food poisoning may be at an increased risk of developing Crohn&#8217;s disease later in life, according to a new study led by researchers at McMaster University.}<\/p>\n<p>Using a mouse model of Crohn&#8217;s disease, the researchers discovered that acute infectious gastroenteritis caused by common food-poisoning bacteria accelerates the growth of adherent-invasive E. coli (AIEC) &#8212; a bacterium that has been linked to the development of Crohn&#8217;s.<\/p>\n<p>Even after the mice had eliminated the food-poisoning bacteria, researchers still observed increased levels of AIEC in the gut, which led to worsened symptoms over a long period of time.<\/p>\n<p>The study, published in the journal PLOS Pathogens, was funded by grants from the Canadian Institutes of Health Research and Crohn&#8217;s and Colitis Canada.<\/p>\n<p>Crohn&#8217;s disease is a debilitating bowel disease characterized by the inflammation of the intestines. Today, one in every 150 Canadians is living with Crohn&#8217;s or colitis, a rate that ranks among the highest worldwide.<\/p>\n<p>&#8220;This is a lifelong disease that often strikes people in their early years, leading to decades of suffering, an increased risk of colorectal cancer, and an increased risk of premature death,&#8221; said Brian Coombes, senior author of the study. At McMaster University he is a professor of biochemistry and biomedical sciences and a researcher at the Michael G. DeGroote Institute for Infectious Disease Research.<\/p>\n<p>The study&#8217;s results, said Coombes, means that new diagnostic tools should be developed to identify AIEC-colonized individuals who may be at greater risk for Crohn&#8217;s disease following an episode of acute infectious gastroenteritis.<\/p>\n<p>&#8220;We need to understand the root origins of this disease &#8212; and to use this information to invigorate a new pipeline of treatments and preventions. It has never been more pressing.&#8221;<\/p>\n<figure class=\"spip-document spip-document-15586 aligncenter\"><img decoding=\"async\" src=\"https:\/\/en-images.igihe.com\/jpg\/161007140324_1_540x360.jpg\" alt=\"Crohn&#039;s disease is a debilitating bowel disease characterized by the inflammation of the intestines.\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>{People who retain a particular bacterium in their gut after a bout of food poisoning may be at an increased risk of developing Crohn&#8217;s disease later in life, according to a new study led by researchers at McMaster University.} Using a mouse model of Crohn&#8217;s disease, the researchers discovered that acute infectious gastroenteritis caused by [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[75],"byline":[2491],"hashtag":[],"class_list":["post-29254","post","type-post","status-publish","format-standard","hentry","category-health","tag-homenews","byline-science-daily"],"bylines":[{"id":2491,"name":"SCIENCE DAILY","slug":"science-daily","description":"","image":{"id":0,"url":"https:\/\/secure.gravatar.com\/avatar\/?s=96&d=mm&f=y&r=g","alt":"Default avatar","title":"Default avatar","caption":"","mime_type":"image\/jpeg","sizes":[]},"user_id":null}],"contributors":[{"id":2491,"name":"SCIENCE DAILY","slug":"science-daily","description":"","image":{"id":0,"url":"https:\/\/secure.gravatar.com\/avatar\/?s=96&d=mm&f=y&r=g","alt":"Default avatar","title":"Default avatar","caption":"","mime_type":"image\/jpeg","sizes":[]},"user_id":null}],"featured_image":null,"_links":{"self":[{"href":"https:\/\/new.igihe.com\/english\/wp-json\/wp\/v2\/posts\/29254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/new.igihe.com\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/new.igihe.com\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/new.igihe.com\/english\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/new.igihe.com\/english\/wp-json\/wp\/v2\/comments?post=29254"}],"version-history":[{"count":0,"href":"https:\/\/new.igihe.com\/english\/wp-json\/wp\/v2\/posts\/29254\/revisions"}],"wp:attachment":[{"href":"https:\/\/new.igihe.com\/english\/wp-json\/wp\/v2\/media?parent=29254"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/new.igihe.com\/english\/wp-json\/wp\/v2\/categories?post=29254"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/new.igihe.com\/english\/wp-json\/wp\/v2\/tags?post=29254"},{"taxonomy":"byline","embeddable":true,"href":"https:\/\/new.igihe.com\/english\/wp-json\/wp\/v2\/byline?post=29254"},{"taxonomy":"hashtag","embeddable":true,"href":"https:\/\/new.igihe.com\/english\/wp-json\/wp\/v2\/hashtag?post=29254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}